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he Institute of Fundamental Technological Research (IPPT)

of the Polish Academy of Sciences was founded in 1953.

The core of its research interests has always been

fundamental research on mechanics and other engineering

science branches such as electronics, acoustics, biotechnology

etc. During the last 60 years the IPPT reached its current position

of the leading Polish research centre in technology and

engineering sciences, well recognised in the scientific

communities of Europe and the world.

In recent years, the activities of the institute have been largely

focused on areas intensively pursued by leading research centres

around the world, including interdisciplinary research. In particular,

this applies to such areas as new intelligent materials and

technologies, nanomaterials and nanofluids, multifunctional

materials, bioinformatics, and diagnostic ultrasound in medicine.

The combination of advanced experimental studies carried out

using high-quality equipment with mathematical methods and

extensive knowledge of computer science enables the

performance of advanced computer simulations for analysis of

very complex systems and processes.

One of the significant research fields at the IPPT is investigations

related to current challenges in the area of health. A number of

research groups at the institute investigate various

multidisciplinary research fields in this area.

The Centre for Biomedical Research

The centre, headed by Professor Tomasz Lipniacki, gathers

experimentalists and theoreticians conducting research in

systems biology and bioengineering. The centre aims to fill the

gap between physics, mathematics and chemistry on one side

and biology and medicine on the other. The group includes

researchers of various backgrounds – mathematicians, computer

scientists, physicists, chemists and biologists. The main research

focus areas are:


Cell signalling, including immune responses, calcium

signalling, kinase pathways, DNA damage responses, and

neuronal signalling. These studies combine experimental

techniques based on live single cell imaging using confocal

microscopy, as well as classical population studies, with

mathematical and numerical modelling involving ordinary and

partial differential equations and stochastic processes;


Investigations of material structures – in particular polymers –

with a perspective of application in tissue engineering as

scaffolds for tissue regeneration. The main focus is on

biomedical engineering and biotechnology, and it is related to

synthetic bioresorbable polymers and biopolymers, the

methods of scaffold formation (e.g. electrospinning of

nanofibres), investigations of their structure and properties,

as well as

in vitro

studies of the biological functionality

of scaffolds;


Analysis of micro and nanoparticles in viscous fluids,

simulations of biochemical processes in membranes, analysis

of dynamical properties of biomacromolecules, including DNA

proteins. Experimental techniques involve atomic force

microscopy and total internal reflection fluorescent microscopy.

This focus also concerns the development of numerical

techniques based on the multipole approach (for

nanoparticles in Stokes flow), molecular dynamics simulation,

and the kinetic Monte Carlo method; and


Development of high-resolution ultrasonic techniques for tissue

and cell diagnostic, therapy and visualisation; live single cell

imaging using acoustic microscopy.

Department of Ultrasounds

Another significant research group, led by Professor Andrzej

Nowicki, is the Department of Ultrasounds. Ultrasound is not only

a complementary method to traditional imaging techniques,

such as X-ray, computed tomography, magnetic resonance or

When it comes to research, the Institute of Fundamental Technological Research

has a focus on health-related research fronts

Health-related research fronts



H O R I Z O N 2 0 2 0 P R O J E C T S : P O R TA L


M E D I C A L T E C H N O L O G Y & R E S E A R C H

Fig. 2 B-scan of the tissue-mimicking phantom with two regions of

increased attenuation (invisible in the greyscale image) and colour

image of attenuation regions after parametric processing

Fig. 1 Example of pathogen recognition: LPS (lipopolysaccharide –

outer membrane of Gram-negative bacteria)-induced signalling