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A variety of tools

Research projects about spectroscopy in dogs,

several diffusion and perfusion techniques,

dynamic examinations of the heart, and highly

detailed representations of particularly small

structures in the 3 Tesla MRI represent only a

selection of the options that can be

implemented at our clinic. We offer modern

imaging modalities like CT or a 3 Tesla MRI

(Philips Ingenia).

In comparison to other low-field MRIs, we work

with a better SNR (signal to noise ratio) in the 3

Tesla MRI. Consequently, there is a significant

improvement in the image quality of standard

MRI sequences, where we reach excellent

resolution. In addition, we follow the approach

of molecular imaging (spectroscopy) as well as

functional MRI. A set of different coils provides

the possibility to scan material of different sizes

(from rodents up to the large parts of a horse).

More advanced sequences, such as DIXON, are

also possible.

In recent years, the demand for documentation

and standardisation of preclinical animal

models has increased. To reach this high level,

different quality assurance programmes have

been introduced, such as good laboratory

practice (GLP), good manufacturing practice

and good clinical practice. In close collaboration

between DIRU and MSRU, it is also possible to

run projects with GLP certification to fulfil high

quality standards of regulatory affairs.

The aim of this clinically applied research is

to translate scientific evidence into

commercial developments. Whether new

surgical techniques, medical implants or

treatment methods are addressed, the use of

modern imaging techniques and modalities

can make an important contribution.

In Fig. 1, the x-axis represents the signature

chemical shift of each metabolite concentration,

M

odern diagnostic imaging techniques are used in veterinary

medicine, similar to those in human medicine, playing an

important role in clinical and research applications. Diagnostic

imaging principally includes radiology, ultrasound, computerised

tomography (CT) and magnetic resonance imaging (MRI).

Historically, new developed imaging modalities have always been

established in veterinary medicine with some delay in comparison to

human medicine. However, radiology and ultrasound have become widely

available in many private veterinary clinics, while advance imaging

modalities, such as CT and MRI, are more often restricted to referral

centres, university institutions and veterinary research centres. Research

in veterinary medicine itself, and with the background of translational

medicine, has an important clinical impact for humans and animals.

Research and imaging

Numerous interdisciplinary projects relevant to human health issues have

already been performed successfully at the Vetsuisse Faculty in Zürich.

A lot of translational studies were done in collaboration with the

Musculoskeletal Research Unit (MSRU) and the Center for Applied

Biotechnology and Molecular Medicine (CABMM).

Issues in imaging play an increasingly important role, which is why the

Clinic of Diagnostic Imaging at the Vetsuisse Faculty Zürich has now

established a department for clinical research under the name Diagnostic

Imaging Research Unit. The DIRU pursues a vision as an innovative and

reliable research partner, which can enable the pursuit of innovative ideas

through quality assurance and transparency in project-based

collaborations. In this function, the DIRU represents a bridge between

academic research and industry, which is well integrated into the network

of the MSRU and the CABMM.

The aim of the DIRU is therefore to support projects based on the tracking

of imaging research and imaging services, both for internal research

groups as well as external partners. The interdisciplinary exchange and

implementation of a network of several other professionals are a major

locational advantage; a close co-operation with the MSRU and

membership in the CABMM can be considered an example. In our

organisation, we have experts from different fields of interests, including

congenital diseases, cardiovascular imaging, liver imaging, perfusion

imaging, musculoskeletal imaging, neuroimaging, interventional imaging

and translational medicine.

I S S U E S E V E N

H O R I Z O N 2 0 2 0 P R O J E C T S : P O R TA L

www.horizon2020projects.com

104

M E D I C A L T E C H N O L O G Y & R E S E A R C H

More than just imaging

The CABMM’s researchers detail a number of investigations into, and the

results of, using proton magnetic resonance spectroscopy on dogs with various

brain conditions