each disease. In this study, we included 15 dogs
with proven neoplasia and 15 dogs with
inflammatory meningoencephalitis, which were
then compared to normal dogs.
There were statistical differences between
diseased and normal dogs. Differences were
also noted between neoplasia
inflammation. The concentration of
acetylaspartate is lower in neoplasia than in
meningoencephalitis, whilst the concentration
of choline is higher in neoplasia than in
In Fig. 4 is a typical short echo time
magnetic resonance spectra of a dog with
granulomatous meningoencephalitis. In this
type of meningoencephalitis, the presence of
lactate is common due to hypoxia. Choline is
slightly elevated, whilst
H MRS of four dogs with
meningoencephalitis showed recovery of
acetylaspartate to normal values, correlated
with the clinical improvement. This proves that
the reduction of
meningoencephalitis may be due to neural
dysfunction, rather than neural death.
Interestingly, in ten out of 15 patients with
meningoencephalitis, taurine was found; this
metabolite was only found in one neoplasia.
Potentially, taurine may serve as a metabolic
marker for patients with meningoencephalitis.
Future projects involving tumours and
meningoencephalitis are the investigation of the
response after treatment.
This investigation focused on the brain
metabolite abnormalities in dogs infected with
tick-borne encephalitis (TBE). Central European
TBE is an infection caused by a
transmitted by tick bites (
various species, including humans, dogs,
horses, sheep and goats; the disease is
endemic in 27 European countries. TBE virus is
a neurotropic RNA virus which causes a
non-suppurative encephalomyelitis in dogs,
characterised by widespread neurophagia and
gliosis throughout the grey matter of the central
nervous system, but mainly involving the
brainstem, cerebellum and ventral horn of the
Ines Carrera, Dr med vet Dip ECVDI
Henning Richter, Dr med vet
Patrick Kircher, Prof Dr med vet Dipl ECVDI
Head CABMM: Professor Dr Brigitte von Rechenberg
University of Zürich
B R OW S Ewww.cabmm.uzh.ch
H O R I Z O N
2 0 2 0www.horizon2020projects.com
H O R I Z O N 2 0 2 0 P R O J E C T S : P O R TA L
I S S U E S E V E N
M E D I C A L T E C H N O L O G Y & R E S E A R C H
Diagnosis of TBE in dogs is very challenging. During the first viremic
phase of the disease, the virus can only be isolated from the blood or
from cerebrospinal fluid (CSF) by reverse-transcriptase-polymerase chain
reaction. During the second phase, when neurological signs become
clinically evident and humoral immune response starts, the virus clears
up from the blood and CSF and cannot be detected anymore.
MRI has been described in both people and dogs. The MRI changes are
very characteristic, showing bilateral symmetrical lesions of the thalamus,
hippocampus and grey matter ventral horn of the spinal cord. However,
MRI may be negative in some patients, even with evident clinical signs.
We are investigating the metabolic changes in dogs with confirmed TBE,
especially those in which there are no evident morphological lesions.
When compared to normal dogs, patients with TBE show a marked
acetylaspartate concentration and higher myo-inositol.
These findings may help to detect brain abnormalities at a metabolic
level, even though conventional MRI is normal.
Fig. 4 Typical short
echo time magnetic
resonance spectra of a