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H O R I Z O N 2 0 2 0 P R O J E C T S : P O R TA L

I S S U E S E V E N

163

P R O F I L E

M E TA B O L I C D I S E A S E S

Ongoing projects include:

n

Development of operational protocols for metabolomic

analyses by orthogonal GC×GC-TOF MS. In collaboration with

LECO Instrumente, Plzen (Czech Republic);

n

The development of mass spectrometry tools. In collaboration

with R Tautenhahn, Y Huang, (Thermo Fisher Scientific, San

Jose, Silicon Valley, CA, USA) and T Pluskal (Okinawa Institute of

Science and Technology, Japan);

n

Understanding pathobiochemistry in patients with medium-

chain acyl-CoA dehydrogenase deficiency. In collaboration with

R Goodacre (University of Manchester, UK);

n

Define biomarkers of brain damage caused by perinatal asphyxia.

In collaboration with Professor J Zeman (First Faculty of Medicine,

Charles University in Prague and General University Hospital in

Prague, Czech Republic) and Dr L Kantor (Department of

Neonatology, Olomouc University Hospital, Faculty of Medicine

and Dentistry, Palacky University, Czech Republic);

n

Improving technologies for metabolomics and software robot

decision algorithms. In collaboration with Dr R Mistrik,

HighChem Ltd. (Bratislava, Slovakia);

n

Defining disease mechanisms and treatment response of

chronic myeloid leukaemia. High-throughput method for

therapeutic drug monitoring. In collaboration with Professor E

Faber (Department of Haemato-Oncology, Olomouc University

Hospital, Faculty of Medicine and Dentistry, Palacky University,

Czech Republic);

n

Development of novel diagnostic methods for inherited

metabolic diseases and automatic workflows;

n

Plasma metabolic profiling of asthmatic and cystic fibrosis

mice models. In collaboration with Professor D Radzioch

(Department of Human Genetics, McGill University, Montreal,

Quebec, Canada);

n

Statistical tools development. In collaboration with Professor

P Filzmoser (Department of Statistics and Probability Theory,

Vienna University of Technology, Vienna, Austria); and

Professor K Hron (Department of Mathematical Analysis

and Applications of Mathematics, Palacky University,

Czech Republic); and

n

Prediction of orthogonality for comprehensive two-dimensional

separations by second-dimension retention indices. In

collaboration with Professor J-M Dimandja (Spelman College,

Atlanta, Georgia, USA).

The team publishes its research results in high impact journals

and presents lectures and posters at both international and

local conferences.

Publications

The most important publications of the group:

1. Kanagaratham C, Kalivodova A

et al

. Fenretinide prevents

inflammation and airway hyperresponsiveness in a mouse

model of allergic asthma.

Am J Respir Cell Mol Biol.

2014;

2. Janeckova H, Hron K

et al.

Targeted metabolomic analysis of

plasma samples for the diagnosis of inherited metabolic

disorders.

J Chromatogr A.

2012;

3.Kvitvang HFN, Andreassen T

et al.

Highly Sensitive GC/MS/MS

Method for Quantitation of Amino and Nonamino Organic

Acids.

Anal. Chem.

2011;

4. Wojtowicz P, Zrostlikova J

et al.

Evaluation of comprehensive

two-dimensional gas chromatography coupled to time-of-flight

mass spectrometry for the diagnosis of inherited metabolic

disorders using an automated data processing strategy.

J Chromatogr A.

2010;

5. Pospisilova D, Cmejlova J

et al.

Successful treatment of a

Diamond-Blackfan anaemia patient with amino acid leucine.

Haematologica 92.

2007;

6. Friedecky D, Tomkova J, Adam T. Determination of ITPase activity

by capillary electrophoresis.

Clin Chem.

2007; and

7. Adam T, Friedecky D, Fairbanks LD, Sevcik J, Bartak P. Capillary

electrophoresis for detection of inherited disorders of purine

and pyrimidine metabolism.

Clin Chem.

1999.

As an academic institution teaching analytical chemistry,

biostatistics and biochemistry, scientific presentation skills are

provided. Students of the Faculty of Science and Faculty of

Medicine and Dentistry are lectured on clinical biochemistry,

medical genetics and bio-analytical methods, and receive

practical guidance throughout bachelor, master's and PhD theses.

Currently, ten PhD students and a number of undergraduate

students are being educated in our laboratory.

ProfessorTomasAdam

Head of the Laboratory of Metabolomics

Institute of Molecular andTranslational Medicine

Faculty of Medicine and Dentistry

Palacky University, Olomouc

Czech Republic

te l :

+420 588444256

tomasadam@gmail.com http://metabol.upol.cz http://metabolom.eu http://metabolom.cz

The most important awards for the laboratory’s work:

n

The prize of the Czech Society for Clinical Biochemistry for

the best publication in 2011; and

n

The prize of the Czech Society for Clinical Biochemistry for

the best publication in 2012.