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H O R I Z O N 2 0 2 0 P R O J E C T S : P O R TA L

I S S U E S E V E N

97

P R O F I L E

M E D I C A L T E C H N O L O G Y & R E S E A R C H

In CARDIS, we will secure and reinforce the industrial technology

leadership and substantially increase the market presence in

diagnostics of Medtronic and SIOS specifically and EU companies

in general.

With Medtronic, SIOS, Imec, Tyndall, UGent, UM and HEGP,

CARDIS is partnering European leaders in medical devices, laser

interferometers, silicon photonics and arterial biomechanics.

CARDIS will help to secure their leadership by developing a new

application that advances the existing background. In this

collaboration, the partners will be sharing their experience

and backgrounds for the purpose of creating a CVD screening

device that they would not be able to develop alone and in the

same timeframe.

This will bring, in our vision, a substantial and life-saving benefit to

subjects at risk of cardiovascular events.

References

1

Yoav Ben-Shlomo

et al.

(2014): Aortic Pulse Wave Velocity Improves

Cardiovascular Event

Prediction.An

Individual Participant Meta-Analysis of

Prospective Observational Data From 17,635 Subjects,

Journal of the

American College of Cardiology,

63:7

2

Laurent S, Cockcroft J,Van BL,

et al.

(2006): Expert consensus document on

arterial stiffness: methodological issues and clinical applications,

Eur Heart J,

27: 2588-605

3

M De Melis, U Morbiducci, L Scalise, E P Tomasi, D Delbeke, R Baets, L M Van

Bortel, P Segers (2008): A noncontact approach for the evaluation of large

artery stiffness: a preliminary study,

American Journal of Hypertension,

21(12): 1280-1283

4

A Campo, P Segers, and J Dirckx (2011): Laser Doppler vibrometry for

in vivo

assessment of arterial stiffness. In IEEE Int.Workshop on Medical

Measurements and Applications Proceedings (MeMeA), 119-121, Bari

5

Foreman J E, Hutchison K J (May 1970): Arterial wall vibration distal to

stenoses in isolated arteries of dog and man,

Circ Res

26(5): 583-90

6

Kirkeeide R L,Young D F, Cholvin N R (1977): Wall vibrations induced by flow

through simulated stenosis in models and arteries,

J Biomech

10(7): 431-41

7

Comess K A, Choi J H, Xie Z,Achenbach S, Daniel W, Beach K W, Kim Y (May

2011): Transthoracic coronary Doppler vibrometry in the evaluation of normal

volunteers and patients with coronary artery stenosis,

Ultrasound Med Biol

37(5): 679-87

8

Greenwald S E, Banks H T, Birch M J, Brewin M P, Hu S, Kenz Z R, Kruse C,

Mehta D, Reeves J, Shaw S,Whiteman J R (1 September 2013): Acoustic

localisation of coronary artery stenosis: Wave propagation in soft tissue

mimicking gels,

Artery Research

7:3: 124

9

Foreman J E, Hutchison K J (May 1970): Arterial wall vibration distal to

stenoses in isolated arteries of dog and man,

Circ Res

26(5): 583-90

10

Bordachar P, Lafitte S, Reuter S, Sanders P, Jaïs P, Haïssaguerre M, Clementy J

(2004): Echocardiographic parameters of ventricular dyssynchrony validation

in patients with heart failure using sequential biventricular pacing,

Journal of

the American College of Cardiology,

44(11): 2157-2165

11

De Melis M, Morbiducci U, Scalise L (2007): Identification of cardiac events

by Optical Vibrocardiograpy: comparison with Phonocardiography. In

Engineering in Medicine and Biology Society (EMBS) 2007;

29th Annual

International Conference of the IEEE: 2956-2959

12

Morbiducci U, Scalise L, De Melis M, Grigioni M (2001): Optical

vibrocardiography: A novel tool for the optical monitoring of cardiac activity,

Annals of biomedical engineering,

35(1): 45-58

Mirko de Melis

Co-ordinator

CARDIS Project

tel :

+31 6122 50871

mirko.de.melis@medtronic.com www.ugent.be/en/news/bulletin/cardis-cardio-vascular- disease-detection.htm

Fig. 2 CARDIS value chain

User needs

Application

expert

Photonic IC

(development +

proyotyping +

low volume

manufact.)

System

(development +

manufacturing)

Device

(development +

manufacturing +

marketing)

User (Usability

and human

proof of con-

cept)